Center for Cancer Systems Biology
at Vanderbilt University
| with the Integrated Mathematical Oncology at the Moffitt Cancer Center |  |
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CCSB@V 5th Hands-on Workshop
5th Hands-on Workshop
"Interrogating Cancer Resistance to Targeted Therapeutics with Systems Biology"
Monday, August 22 thru Wednesday, August 24, 2011
Vanderbilt-Ingram Cancer Center (VICC)
2220 Pierce Ave
898 J Preston Research Building
Nashville, Tennessee 37232
Workshop Objective
The 5th annual Hands-on Workshop will be held at the Vanderbilt University campus and will focus on the clinical challenge of acquired resistance to treatment with molecular targeted therapeutics in cancer patients. The workshop will particularly focus on the added value of systems biology tools to decipher novel strategies to combat development of resistance. The workshop’s “hands-on” approach aims at the design, construction and implementation of existing and novel systems biology tools (e.g., mathematical/computational models, signaling network reconstruction and modeling, bioinformatics) by the workshop participants who will be grouped into interdisciplinary teams (clinicians, experimentalists, modelers). The workshop is particularly intended to reach young investigators both in the biomedical and quantitative sciences with an interest in cancer. Furthermore, there will be a unique mix of clinical/surgical oncologists with systems biologists, since we will encourage participation of Vanderbilt-resident clinicians with direct efforts in targeted therapeutics clinical trials.
Workshop Goals
The goals of this activity are to:
1) Recognize the impact of resistance to treatment of cancer patients;
2) Incorporate the knowledge gained into quantitative models by applying systems biology theory and tools; and
3) Cultivate interdisciplinary collaboration to promote the exchange of ideas, information and practical solutions.
Program Schedule
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Monday, August 22, 2011 Room: 898 J Preston Research Building |
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8:00 AM - 8:45 AM |
BREAKFAST |
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8:45 AM - 9:00 AM |
WELCOME REMARKS Vito Quaranta, M.D., Director CCSB@V Lourdes Estrada, PhD, SEC CCSB@V |
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9:00 AM - 9:25 AM |
Carlos L. Arteaga, MD Pre-surgical trials in breast cancer: Role in discovery of mechanisms of drug resistance |
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9:30 AM - 9:55 AM |
Kevin A. Janes, PhD A dynamic JUNDÐ TGFBR3 expression circuit in single basal-like breast epithelial cells |
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10:00 AM - 10:15 AM |
BREAK |
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10:15 AM - 10:40 AM |
William Pao, MD, PhD Novel strategies to delay/treat acquired resistance to EGFR TKIs in EGFR mutant lung cancer |
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10:45 AM - 11:10 AM |
Darren R. Tyson, PhD A method to quantify population-level cell proliferation dynamics from single-cell data |
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11:15 AM - 11:40 AM |
Bing Zhang, PhD Network-based approaches to cancer mechanisms and therapeutics |
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11:45 AM - 12:55 PM |
LUNCH |
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1:00 PM - 1:25 PM |
Jeffrey A. Sosman, MD Overcoming Drug Resistance in Melanoma |
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1:30 PM - 1:55 PM |
Cory M. Johannessen, PhD Systematic, functional biological approaches to identify mechanisms of drug resistance in malignant melanoma |
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2:00 PM - 2:25 PM |
Wendell G. Yarbrough, MD, FACS, MMHC Cancer biobanking and modeling: Utility for developing targeted therapy |
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2:30 PM - 2:55 PM |
Julia D. Wulfkuhle, PhD The Reverse-Phase Protein Microarray Platform: Applications in Clinical Studies for Monitoring Response and Resistance to Therapy |
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3:00 PM - 3:25 PM |
William S. Hlavacek, PhD Mechanistic Network Models of Signaling Networks |
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3:30 PM - 3:45 PM |
BREAK |
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3:45 PM - 4:10 PM |
David P. Carbone, MD, PhD Matching patients to therapies in non-small cell lung cancer |
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4:15 PM - 4:40 PM |
Lani Wu, PhD Quantifying Lung Cancer Cellular Response Heterogeneity? |
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4:45 PM - 5:10 PM |
Michael Blinov, PhD Spatial modeling of signaling networks |
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5:15 PM - 5:30 PM |
Working Groups Assembly |
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Tuesday, August 23, 2011 Rooms: 898J PRB, 898I PRB, 749 PRB |
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8:00 AM - 8:45 AM |
BREAKFAST |
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9:00 AM - 11:55 AM |
Working Group Session I (BREAK at 10:30 AM) |
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12:00 PM - 1:00 PM |
LUNCH |
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1:00 PM - 5:00 PM |
Working Group Session II (BREAK at 3:00 PM) |
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Wednesday, August 24, 2011 Rooms: 898J PRB, 898I PRB, 898K PRB |
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8:00 AM - 8:45 AM |
BREAKFAST |
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9:00 AM - 11:55 AM |
Working Group Session III (BREAK at 10:30 AM) |
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12:00 PM - 1:00 PM |
LUNCH |
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1:00 PM - 1:25 PM |
Group I Presentation |
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1:30 PM - 1:55 PM |
Group II Presentation |
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2:00 PM - 2:25 PM |
Group III Presentation |
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2:30 PM - 3:00 PM |
Closing Remarks, Group Picture and Departure |
Lodging
The Nashville Marriott at Vanderbilt University will be the host lodging facility for the Center for Cancer Systems Biology @ Vanderbilt 5th Hands-on Workshop.
You may secure lodging arrangements by contacting Marriot Central Reservation at 1-800 228-9290 and refer to the Meeting Group Code: “NCINCIA” - Vanderbilt Workshop or click on the link provided below.
http://www.marriott.com/hotels/travel/bnaav?groupCode=ncincia&app=resvli...
The conference rate for attendees is $110 single or double occupancy. There is an additional charge of $19.27 for occupancy and sales tax.
Nashville Marriott at Vanderbilt University
2555 West End Avenue
Nashville, TN 37203
(615) 321-1300
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